1 H and 19 F NMR in drug stress testing: the case of voriconazole
Stress tests form an important part of drug development, and of subsequent accreditation. Commonly the change in chemical composition over time is determined using chromatographic methods that separate the mixture components, but when structural characterization of the degradation products is requir...
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Veröffentlicht in: | RSC advances 2017, Vol.7 (54), p.34000-34004 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Stress tests form an important part of drug development, and of subsequent accreditation. Commonly the change in chemical composition over time is determined using chromatographic methods that separate the mixture components, but when structural characterization of the degradation products is required, other methods are needed. Arguably the most powerful method for determining chemical structure information is NMR spectroscopy. Here we show that NMR alone, using a combination of simple
19
F,
1
H, and DOSY experiments, can characterise both structure and kinetics of an intact reaction mixture, without the need for any physical separation. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/C7RA03822D |