Diastereoselective [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF 2 HCHN 2 : syntheses of CF 2 H-containing spirooxindoles

Diastereoselective [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF 2 HCHN 2 : syntheses of CF 2 H-containing spirooxindoles

An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF HCHN for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CF H group and three contiguous stereogenic centers in up to 84% y...

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Veröffentlicht in:Organic & biomolecular chemistry 2017-07, Vol.15 (26), p.5571-5578
Hauptverfasser: Han, Wen-Yong, Zhao, Jia, Wang, Jian-Shu, Xiang, Guang-Yan, Zhang, Ding-Lei, Bai, Mei, Cui, Bao-Dong, Wan, Nan-Wei, Chen, Yong-Zheng
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Sprache:eng
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Zusammenfassung:An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF HCHN for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CF H group and three contiguous stereogenic centers in up to 84% yield and 99 : 1 trans/cis.
ISSN:1477-0520
1477-0539
DOI:10.1039/C7OB01266G