A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125 I-imaging agents

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125 I-imaging agents

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-10, Vol.53 (80), p.11008-11011
Hauptverfasser: Sloan, Nikki L, Luthra, Sajinder K, McRobbie, Graeme, Pimlott, Sally L, Sutherland, Andrew
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container_issue 80
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container_title Chemical communications (Cambridge, England)
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creator Sloan, Nikki L
Luthra, Sajinder K
McRobbie, Graeme
Pimlott, Sally L
Sutherland, Andrew
description An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of I-labelled aryl compounds and SPECT radiotracers.
doi_str_mv 10.1039/C7CC06211G
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125 I-imaging agents
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