A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125 I-imaging agents

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125 I-imaging agents

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-10, Vol.53 (80), p.11008-11011
Hauptverfasser: Sloan, Nikki L, Luthra, Sajinder K, McRobbie, Graeme, Pimlott, Sally L, Sutherland, Andrew
Format: Artikel
Sprache:eng
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Zusammenfassung:An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of I-labelled aryl compounds and SPECT radiotracers.
ISSN:1359-7345
1364-548X
DOI:10.1039/C7CC06211G