Rh III -Catalyzed site-selective amidation with nitrone as a traceless directing group: an approach to functionalized arylaldehydes
An efficient Rh-catalyzed site-selective amidation of nitrones with 1,4,2-dioxazol-5-ones has been developed. The reaction can tolerate a number of groups and generates functionalized aldehydes in good yields. The significance of the amidation is highlighted by the late-stage transformation of the f...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2017-09, Vol.53 (74), p.10322-10325 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | An efficient Rh-catalyzed site-selective amidation of nitrones with 1,4,2-dioxazol-5-ones has been developed. The reaction can tolerate a number of groups and generates functionalized aldehydes in good yields. The significance of the amidation is highlighted by the late-stage transformation of the formed aldehydes. |
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| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/c7cc05297a |