Dicarboxylic acids as pH sensors for hyperpolarized 13 C magnetic resonance spectroscopic imaging

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2- C,D ]diethylmalonic acid, which exhibits a large pH-dependent C chemical shift over the physiological range. We demonstrate that co-polarization with [1-...

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Veröffentlicht in:	Analyst (London) 2017-05, Vol.142 (9), p.1429-1433
Hauptverfasser:	Korenchan, D E, Taglang, C, von Morze, C, Blecha, J E, Gordon, J W, Sriram, R, Larson, P E Z, Vigneron, D B, VanBrocklin, H F, Kurhanewicz, J, Wilson, D M, Flavell, R R
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Isotopes - chemistry Dicarboxylic Acids - chemistry Hydrogen-Ion Concentration Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Phantoms, Imaging
Online-Zugang:	Volltext
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Zusammenfassung:	Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2- C,D ]diethylmalonic acid, which exhibits a large pH-dependent C chemical shift over the physiological range. We demonstrate that co-polarization with [1- C,D ]tert-butanol accurately measures pH via C NMR and magnetic resonance spectroscopic imaging in phantoms.
ISSN:	0003-2654 1364-5528
DOI:	10.1039/c7an00076f