Glucose-responsive microgels based on apo-enzyme recognition

Glucose-responsive polymer microgels that can undergo highly selective, reversible, and rapid volume phase transitions in response to fluctuations in blood glucose concentration have the potential to regulate insulin delivery to improve patient compliance and health. Herein, we report such a glucose...

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Veröffentlicht in:Polymer chemistry 2016-01, Vol.7 (16), p.2847-2857
Hauptverfasser: Ye, Ting, Bai, Xue, Jiang, Xiaomei, Wu, Qingshi, Chen, Shoumin, Qu, Anqi, Huang, Junwei, Shen, Jing, Wu, Weitai
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Sprache:eng
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Zusammenfassung:Glucose-responsive polymer microgels that can undergo highly selective, reversible, and rapid volume phase transitions in response to fluctuations in blood glucose concentration have the potential to regulate insulin delivery to improve patient compliance and health. Herein, we report such a glucose-responsive polymer microgel, which is made of a representative apo-enzyme, apo-glucose oxidase (apo-GOx), interpenetrated in a chemically-crosslinked network of poly( N -isopropylacrylamide) (pNIPAM). Introduction of apo-GOx into the pNIPAM network made the newly developed semi-interpenetrating-structured microgels responsive with high selectivity to glucose over a glucose concentration range of 020 mM at a physiological pH value of 7.4. While the microgels could swell and reach stability shortly (
ISSN:1759-9954
1759-9962
DOI:10.1039/c6py00179c