New [(η-CH)Ru(N-N)(PPh)][PF] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes

Eight ruthenium( ii ) compounds of the general formula [(η 5 -C 5 H 5 )Ru(N-N)(PPh 3 )][PF 6 ] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC 50 between 14.56 and 1.56 μM; importantly, compounds 5Ru and 6Ru are the first reported ruthenium gly...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2016-07, Vol.45 (3), p.11926-1193
Hauptverfasser:	Florindo, Pedro R, Pereira, Diane M, Borralho, Pedro M, Costa, Paulo J, Piedade, M. F. M, Rodrigues, Cecília M. P, Fernandes, Ana C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Biological Transport Cancer Carbohydrates Carbohydrates - chemistry Cellular Colon Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Coordination Complexes - chemistry Coordination Complexes - therapeutic use Glucose HCT116 Cells Humans Models, Molecular Monosaccharide Transport Proteins - metabolism Ruthenium Ruthenium Compounds - chemistry Uptakes
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Beschreibung
Zusammenfassung:	Eight ruthenium( ii ) compounds of the general formula [(η 5 -C 5 H 5 )Ru(N-N)(PPh 3 )][PF 6 ] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC 50 between 14.56 and 1.56 μM; importantly, compounds 5Ru and 6Ru are the first reported ruthenium glycoconjugates exploiting glucose transporters, widely overexpressed in cancer, for cellular uptake. Ruthenium glycoconjugates, with privileged passage through HCT116 colon cancer cell membranes via glucose transporters, are reported.
ISSN:	1477-9226 1477-9234
DOI:	10.1039/c6dt01571a