A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control

A novel anticancer pro-prodrug (GMC-CA E -NO 2 ) with diagnosis and therapy functions based on hypoxia and photo sequential control was designed. It provides a platform for constructing theranostic pro-prodrugs to release active drugs controlled by hypoxic status and UV illumination. A novel antican...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (6), p.9434-9437
Hauptverfasser:	Feng, Weipei, Gao, Chunyue, Liu, Wei, Ren, Huihui, Wang, Chao, Ge, Kun, Li, Shenghui, Zhou, Guoqiang, Li, Hongyan, Wang, Shuxiang, Jia, Guang, Li, Zhenhua, Zhang, Jinchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Survival - drug effects Construction Diagnosis Humans Hypoxia Hypoxia - diagnosis Hypoxia - drug therapy Illumination MCF-7 Cells Photochemical Processes Platforms Prodrugs - chemistry Prodrugs - pharmacology Prodrugs - therapeutic use Sequential control Theranostic Nanomedicine Therapy
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Zusammenfassung:	A novel anticancer pro-prodrug (GMC-CA E -NO 2 ) with diagnosis and therapy functions based on hypoxia and photo sequential control was designed. It provides a platform for constructing theranostic pro-prodrugs to release active drugs controlled by hypoxic status and UV illumination. A novel anticancer theranostic pro-prodrug (GMC-CA E -NO 2 ) based on hypoxia and photo sequential control was designed.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c6cc02932a