Tailoring a two-dimensional graphene oxide surface: dual T 1 and T 2 MRI contrast agent materials

A generalized strategy for developing a hybrid two-dimensional nanostructured dual T -T MRI contrast agent (CA), by co-loading graphene oxide with both Mn-doped Fe O (T agent) and MnO (T agent) magnetic nanoparticles, is reported. Typical T /T signal quenching, due to magnetic coupling, was not observed because of the fair T CA separation distance from the T CA on the graphene oxide. The resultant two-dimensional nanostructured MRI CA complements the existing dual T -T MRI CA libraries.