Synthesis and characterization of bioreducible heparin-polyethyleneimine nanogels: application as imaging-guided photosensitizer delivery vehicle in photodynamic therapy

Herein, we synthesized and characterized novel bioreducible heparin polyethyleneimine (HPC) nanogels consisting of heparin, branched polyethyleneimine (PEI) and l -cysteine. 1 H-NMR and FTIR analysis confirmed the formation of HPC nanogels while TEM and dynamic light scattering revealed uniform sphe...

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Veröffentlicht in:RSC advances 2016-01, Vol.6 (18), p.14692-1474
Hauptverfasser: Debele, Tilahun Ayane, Mekuria, Shewaye Lakew, Lin, Shuian-Yin, Tsai, Hsieh-Chih
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Sprache:eng
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Zusammenfassung:Herein, we synthesized and characterized novel bioreducible heparin polyethyleneimine (HPC) nanogels consisting of heparin, branched polyethyleneimine (PEI) and l -cysteine. 1 H-NMR and FTIR analysis confirmed the formation of HPC nanogels while TEM and dynamic light scattering revealed uniform spherical nanoparticles with average diameter of
ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra25650j