Rapid access to unsymmetrical 1,3-diynes and 2,5-disubstituted thiophenes under ligand and Pd/Ni-free Cu-catalysis

Rapid access to unsymmetrical 1,3-diynes and 2,5-disubstituted thiophenes under ligand and Pd/Ni-free Cu-catalysis

A Pd/Ni-free copper-catalysed tandem synthesis was realized for rapid access to unsymmetrical 1,3-diynes from 1,1-dibromoalkenes and terminal alkynes. This method was extended to the straightforward synthesis of unsymmetrical 2,5-disubstituted thiophenes in a one-pot operation.

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Veröffentlicht in:RSC advances 2015-01, Vol.5 (95), p.78090-78098
Hauptverfasser: Rao, Maddali L. N., Islam, Sk Shamim, Dasgupta, Priyabrata
Format: Artikel
Sprache:eng
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Zusammenfassung:A Pd/Ni-free copper-catalysed tandem synthesis was realized for rapid access to unsymmetrical 1,3-diynes from 1,1-dibromoalkenes and terminal alkynes. This method was extended to the straightforward synthesis of unsymmetrical 2,5-disubstituted thiophenes in a one-pot operation.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA15705F