A Ru() - catalyzed α-cross-coupling aldol type addition reaction of activated olefins with isatins

A α-cross-coupling aldol type addition reaction activated olefins with isatins has been described in the presence of ruthenium( iii ) chloride and tributyltin hydride (TBTH) at room temperature. This method is found to work consistently for the delivering of ene-carbonyl coupled products in good to excellent yields with moderate to acceptable selectivity. The substrate scope of the present method was briefly discussed. A α-cross-coupling aldol type addition reaction activated olefins with isatins has been described in the presence of ruthenium( iii ) chloride and tributyltin hydride (TBTH) at room temperature.