Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-ones using oxygen as the oxidant

Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidin-4-ones using oxygen as the oxidant

A direct C-3 alkenylation of 2-methyl-4 H -pyrido[1,2- a ]pyrimidin-4-ones through palladium-catalyzed C–H activation using oxygen as the terminal oxidant has been developed. This method provides an easy access to functionalized new 2-methyl-4 H -pyrido[1,2- a ]pyrimidin-4-one derivatives.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:RSC advances 2015, Vol.5 (46), p.36171-36174
Hauptverfasser: Lv, Junliang, Liang, Ying, He, Peiling, Cai, Zhihao, Liu, Jianwen, Huang, Fengxi
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A direct C-3 alkenylation of 2-methyl-4 H -pyrido[1,2- a ]pyrimidin-4-ones through palladium-catalyzed C–H activation using oxygen as the terminal oxidant has been developed. This method provides an easy access to functionalized new 2-methyl-4 H -pyrido[1,2- a ]pyrimidin-4-one derivatives.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA02932E