A simple protocol for Cu-catalyzed protodecarboxylation of (hetero)aromatic carboxylic acids

A simple and practical protodecarboxylation of o -nitrobenzoic acids as well as heteroaromatic carboxylic acids with various substituents via using CuI/Et 3 N has been established. This transformation provides a viable and low-cost approach to generating previously unavailable substituted arenes from readily accessible aryl carboxylic acids as the starting materials.