An activated coumarin-enamine Michael acceptor for CN

An activated coumarin-enamine Michael acceptor for CN

Two coumarin-enamine chemodosimeters have been synthesized in three steps. They have been shown to selectively detect the cyanide ion with a fluorescent response ( t 1/2 = 20 s) and a limit of detection approximately 4.2 ppb in DMSO. The X-ray crystal structure of the thermodynamically stable E -(ke...

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Veröffentlicht in:New journal of chemistry 2014-10, Vol.38 (10), p.4678-4683
Hauptverfasser: Davis, Aaron B., Lambert, Rachel E., Fronczek, Frank R., Cragg, Peter J., Wallace, Karl J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Two coumarin-enamine chemodosimeters have been synthesized in three steps. They have been shown to selectively detect the cyanide ion with a fluorescent response ( t 1/2 = 20 s) and a limit of detection approximately 4.2 ppb in DMSO. The X-ray crystal structure of the thermodynamically stable E -(keto) enamine isomer of one compound was obtained and exhibited offset π-stacking.
ISSN:1144-0546
1369-9261
DOI:10.1039/C4NJ00862F