Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-β-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity...

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Veröffentlicht in:MedChemComm 2015, Vol.6 (1), p.120-130
Hauptverfasser: Jardim, Guilherme A. M., Guimarães, Tiago T., Pinto, Maria do Carmo F. R., Cavalcanti, Bruno C., de Farias, Kaio M., Pessoa, Claudia, Gatto, Claudia C., Nair, Divya K., Namboothiri, Irishi N. N., da Silva Júnior, Eufrânio N.
Format: Artikel
Sprache:eng
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Zusammenfassung:Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-β-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.
ISSN:2040-2503
2040-2511
DOI:10.1039/C4MD00371C