Single-base mismatch discrimination by T7 exonuclease with target cyclic amplification detection

T7 exonuclease is reported for the first time to have high specificity in discriminating single-base mismatch and utilized for developing a target cyclic amplification biosensor strategy for sensitive SNP detection based on graphene oxide quenching of uncleaved probes. T7 exonuclease is reported for...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-02, Vol.51 (14), p.2954-2956
Hauptverfasser:	Wu, Zhen-Kun, Zhou, Dian-Ming, Wu, Zhan, Chu, Xia, Yu, Ru-Qin, Jiang, Jian-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Biosensing Techniques - methods Biosensors Discrimination Electrochemistry Exodeoxyribonucleases - metabolism Graphene Graphite - chemistry Kinetics Mutation Nucleic Acid Amplification Techniques Oxides Oxides - chemistry Polymorphism, Single Nucleotide Quenching Strategy Target detection
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