An amphiphilic, catalytically active, vitamin B 12 derivative
We performed the reaction of vitamin B 12 with N , N -dimethylformamide dimethyl acetal for primary amide activation, and added MeOH as a nucleophile, to afford cobalester, the first amphiphilic cobalamin derivative. The unique combination of redox properties and solubility represents an asset for i...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2014, Vol.50 (36), p.4674-4676 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | We performed the reaction of vitamin B
12
with
N
,
N
-dimethylformamide dimethyl acetal for primary amide activation, and added MeOH as a nucleophile, to afford cobalester, the first amphiphilic cobalamin derivative. The unique combination of redox properties and solubility represents an asset for its use as a catalyst in C–C bond forming reactions. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/C4CC01064G |