Organelle-selective fluorescent Cu 2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Organelle-selective fluorescent Cu 2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Two novel Cu 2+ sensors, 1 and 2 , bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu 2+ sensing. The ER-selective Cu 2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and rol...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014, Vol.50 (24), p.3197-3200
Hauptverfasser: Lee, Yun Hak, Park, Nayoung, Park, Young Bin, Hwang, Yu Jeong, Kang, Chulhun, Kim, Jong Seung
Format: Artikel
Sprache:eng
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Zusammenfassung:Two novel Cu 2+ sensors, 1 and 2 , bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu 2+ sensing. The ER-selective Cu 2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.
ISSN:1359-7345
1364-548X
DOI:10.1039/C4CC00091A