Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs

Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs

Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by r...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (1), p.71-73
Hauptverfasser: Park, Kyeng Min, Suh, Kyungwon, Jung, Hyuntae, Lee, Don-Wook, Ahn, Youngjoo, Kim, Jeeyeon, Baek, Kangkyun, Kim, Kimoon
Format: Artikel
Sprache:eng
Schlagworte:
Coloring Agents
Cytoplasm - drug effects
Cytoplasm - metabolism
Drug Delivery Systems
HeLa Cells
Humans
Macrocyclic Compounds - chemistry
Microscopy, Confocal
Nanoparticles - chemistry
Oxazines
Particle Size
Pharmaceutical Preparations - chemistry
Pharmaceutical Vehicles - chemistry
Photochemistry
Solubility
Water
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Zusammenfassung:Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by receptor-mediated endocytosis, and (4) facile release of drugs into cytoplasm, which enhances the pharmaceutical effects of the drugs.
ISSN:1359-7345
1364-548X
DOI:10.1039/b815009e