Prospective cohort study of the relationship of markers of insulin resistance and secretion with weight gain and changes in regional adiposity

To examine whether fasting insulin concentrations and markers of first-phase insulin secretion are associated with weight gain and changes in distribution of adiposity over 4.4y. Longitudinal prospective population-based cohort study of middle-aged Caucasians. 767 subjects (40-65y at baseline) were followed up for a mean of 4.4y. 75 g oral glucose tolerance test performed at baseline and follow-up. Insulin was measured at fasting, and 30 and 120 min post-glucose load using a highly specific assay. Fasting insulin levels were correlated with baseline weight (r = 0.32, P