Epoxyeicosatrienoic acids mediate adenosine‐induced vasodilation in rat preglomerular microvessels (PGMV) via A 2A receptors

Epoxyeicosatrienoic acids mediate adenosine‐induced vasodilation in rat preglomerular microvessels (PGMV) via A 2A receptors

Activation of rat adenosine 2A receptors (A 2A R) dilates preglomerular microvessels (PGMV), an effect mediated by epoxyeicosatrienoic acids (EETs). Incubation of PGMV with a selective A 2A R agonist, 2‐ p ‐(2‐carboxyethyl) phenethylamino‐5′‐ N ‐ethylcarboxamidoadenosine (CGS 21680; 100 μ M ), incre...

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Veröffentlicht in:British journal of pharmacology 2009-01, Vol.141 (3), p.441-448
Hauptverfasser: Cheng, M K, Doumad, A B, Jiang, H, Falck, J R, McGiff, J C, Carroll, M A
Format: Artikel
Sprache:eng
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Zusammenfassung:Activation of rat adenosine 2A receptors (A 2A R) dilates preglomerular microvessels (PGMV), an effect mediated by epoxyeicosatrienoic acids (EETs). Incubation of PGMV with a selective A 2A R agonist, 2‐ p ‐(2‐carboxyethyl) phenethylamino‐5′‐ N ‐ethylcarboxamidoadenosine (CGS 21680; 100 μ M ), increased isolated PGMV EET levels to 7.57±1.53 ng mg −1 protein from 1.06±0.22 ng mg −1 protein in controls ( P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0705640