Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of I to1 in cardiac electrogenesis

Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of I to1 in cardiac electrogenesis

In the present study, two new peptides, phrixotoxins PaTx1 and PaTx2 (29–31 amino acids), which potently block A‐type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus . Phrixotoxins specifically block Kv4.3 and Kv4.2 currents that underlie I to1 , with an...

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Veröffentlicht in:British journal of pharmacology 2009-01, Vol.126 (1), p.251-263
Hauptverfasser: Diochot, Sylvie, Drici, Milou‐Daniel, Moinier, Danielle, Fink, Michel, Lazdunski, Michel
Format: Artikel
Sprache:eng
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Zusammenfassung:In the present study, two new peptides, phrixotoxins PaTx1 and PaTx2 (29–31 amino acids), which potently block A‐type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus . Phrixotoxins specifically block Kv4.3 and Kv4.2 currents that underlie I to1 , with an 5
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0702283