Pharmacological analysis of the haemodynamic effects of 5‐HT 1B/D receptor agonists in the normotensive rat
The receptors involved in mediating the haemodynamic effects of three 5‐HT 1B/D receptor agonists were investigated in pentobarbitone anaesthetized rats ( n =6–17 per group). Cumulative intravenous (i.v.) infusions of rizatriptan and sumatriptan (from 0.63 to 2500 μg kg −1 ; each dose over 5 min) in...
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| Veröffentlicht in: | British journal of pharmacology 2009-02, Vol.123 (2), p.205-214 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The receptors involved in mediating the haemodynamic effects of three 5‐HT
1B/D
receptor agonists were investigated in pentobarbitone anaesthetized rats (
n
=6–17 per group).
Cumulative intravenous (i.v.) infusions of rizatriptan and sumatriptan (from 0.63 to 2500 μg kg
−1
; each dose over 5 min) induced dose‐dependent and marked hypotension (−42±6 and −34±4 mmHg at the highest dose, respectively; both
P |
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| ISSN: | 0007-1188 1476-5381 |
| DOI: | 10.1038/sj.bjp.0701593 |