Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men
We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable...
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| Veröffentlicht in: | British journal of cancer 2003-06, Vol.88 (11), p.1682-1686 |
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| container_end_page | 1686 |
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| container_issue | 11 |
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| container_title | British journal of cancer |
| container_volume | 88 |
| creator | Gunnell, D Oliver, S E Peters, T J Donovan, J L Persad, R Maynard, M Gillatt, D Pearce, A Hamdy, F C Neal, D E Holly, J M P |
| description | We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations. |
| doi_str_mv | 10.1038/sj.bjc.6600946 |
| format | Article |
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A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><date>2003-06-02</date><risdate>2003</risdate><volume>88</volume><issue>11</issue><spage>1682</spage><epage>1686</epage><pages>1682-1686</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/sj.bjc.6600946</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Nature Journals Online; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Molecular Medicine Oncology short-communication |
| title | Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men |
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