Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable...

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Veröffentlicht in:British journal of cancer 2003-06, Vol.88 (11), p.1682-1686
Hauptverfasser: Gunnell, D, Oliver, S E, Peters, T J, Donovan, J L, Persad, R, Maynard, M, Gillatt, D, Pearce, A, Hamdy, F C, Neal, D E, Holly, J M P
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Drug Resistance
Epidemiology
Molecular Medicine
Oncology
short-communication
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Zusammenfassung:We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600946