Radical control for enantioselective Csp3–Csp3 cross-coupling
The enantioselective formation of C sp 3 –C sp 3 bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino C sp 3 −H bonds that promotes the generation of two different alkyl radicals,...
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| Veröffentlicht in: | Nature catalysis 2024-08, Vol.7 (8), p.857-859 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The enantioselective formation of C
sp
3
–C
sp
3
bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino C
sp
3
−H bonds that promotes the generation of two different alkyl radicals, followed by their cross-coupling at a chiral nickel centre. |
|---|---|
| ISSN: | 2520-1158 2520-1158 |
| DOI: | 10.1038/s41929-024-01208-2 |