Profiling oncogenic extra-chromosomal DNA in cancer

Profiling oncogenic extra-chromosomal DNA in cancer

Cancer cells frequently amplify oncogenes on DNA molecules outside of chromosomes — extrachromosomal DNA. A technique adapted for isolation of extrachromosomal DNA, termed CRISPR-CATCH, enables analyses of its genetic and epigenetic compositions, which provides insights into its origin, structural d...

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Veröffentlicht in:Nature genetics 2022-11, Vol.54 (11), p.1591-1592
Format: Artikel
Sprache:eng
Schlagworte:
631/1647/2230
631/208/212
631/337/176
631/67/395
Agriculture
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinogenesis - genetics
DNA
Gene Function
Human Genetics
Humans
Neoplasms - genetics
Oncogenes
Research Briefing
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Beschreibung
Zusammenfassung:Cancer cells frequently amplify oncogenes on DNA molecules outside of chromosomes — extrachromosomal DNA. A technique adapted for isolation of extrachromosomal DNA, termed CRISPR-CATCH, enables analyses of its genetic and epigenetic compositions, which provides insights into its origin, structural diversity and mechanism of oncogene activation in cancer.
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-022-01193-x