Mg2+–Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactions

Mg2+–Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactions

Here we show how Mg 2+ and Mn 2+ function in Escherichia coli phosphoenolpyruvate carboxykinase (PCK) and we propose a general model for the role of binuclear metal clusters in enzyme-catalyzed phosphoryl-transfer reactions.

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Veröffentlicht in:Nature Structural Biology 1997-12, Vol.4 (12), p.990-994
Hauptverfasser: Tari, Leslie W., Matte, Allan, Goldie, Hughes, Delbaere, Louis T.J.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
correspondence
Life Sciences
Membrane Biology
Protein Structure
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Zusammenfassung:Here we show how Mg 2+ and Mn 2+ function in Escherichia coli phosphoenolpyruvate carboxykinase (PCK) and we propose a general model for the role of binuclear metal clusters in enzyme-catalyzed phosphoryl-transfer reactions.
ISSN:1072-8368
1545-9985
DOI:10.1038/nsb1297-990