Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli

Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli

The structure of an inactive mutant, heat-labile enterotoxin raises the possibility of a direct functional role for an internal, water-filled cavity.

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Bibliographische Detailangaben
Veröffentlicht in:Nature Structural Biology 1995-04, Vol.2 (4), p.269-272
Hauptverfasser: Merritt, Ethan A, Sarfaty, Steve, Pizza, Mariagrazia, Domenighini, Mario, Rappuoli, Rino, Hol, Wim G.J
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Bacterial Toxins - chemistry
Bacterial Toxins - toxicity
Binding Sites
Biochemistry
Biological Microscopy
correspondence
Crystallography, X-Ray
Enterotoxins - chemistry
Enterotoxins - toxicity
Escherichia coli
Escherichia coli Proteins
Life Sciences
Lysine
Macromolecular Substances
Membrane Biology
Models, Molecular
Mutagenesis, Site-Directed
Point Mutation
Protein Conformation
Protein Structure
Recombinant Proteins - chemistry
Recombinant Proteins - toxicity
Valine
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Beschreibung
Zusammenfassung:The structure of an inactive mutant, heat-labile enterotoxin raises the possibility of a direct functional role for an internal, water-filled cavity.
ISSN:1072-8368
1545-9993
2331-365X
1545-9985
DOI:10.1038/nsb0495-269