Non-synchronized Suppression of Postnatal Activity in Non-allelic Genes which Synthesize the Gγ Chain in Human Foetal Haemoglobin

Non-synchronized Suppression of Postnatal Activity in Non-allelic Genes which Synthesize the Gγ Chain in Human Foetal Haemoglobin

HUMAN foetal haemoglobin (Hb-F) of the newborn is a heterogeneous protein, with two types of γ chains differing minimally in position 136 which is occupied either by a glycyl residue or by an alanyl residue 1 . The phenomenon is worldwide and is not limited to specific races or geographic areas 2 ....

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Veröffentlicht in:Nature. New biology (London) 1973-07, Vol.244 (133), p.89-90
Hauptverfasser: SCHROEDER, W. A., BANNISTER, W. H., GRECH, J. L., BROWN, A. K., WRIGHTSTONE, R. N., HUISMAN, T. H. J.
Format: Artikel
Sprache:eng
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Biomedical and Life Sciences
letters-to-editor
Life Sciences
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Zusammenfassung:HUMAN foetal haemoglobin (Hb-F) of the newborn is a heterogeneous protein, with two types of γ chains differing minimally in position 136 which is occupied either by a glycyl residue or by an alanyl residue 1 . The phenomenon is worldwide and is not limited to specific races or geographic areas 2 . This and other evidence points to the two types of γ chains, termed the G γ and A γ chains, being the products of non-allelic structural genes 1 .
ISSN:0090-0028
2058-1092
DOI:10.1038/newbio244089a0