Jump-starting CoA biosynthesis

Jump-starting CoA biosynthesis

The essential metabolic cofactor coenzyme A was believed to be produced by biosynthesis from pantothenate in all eukaryotic cells. Rescue experiments in systems depleted of CoA have shown that a phosphorylated CoA biosynthetic intermediate can pass through eukaryotic membranes to serve as an alterna...

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Veröffentlicht in:Nature chemical biology 2015-09, Vol.11 (10), p.757-758
Hauptverfasser: de Villiers, Marianne, Strauss, Erick
Format: Artikel
Sprache:eng
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Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry/Food Science
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Zusammenfassung:The essential metabolic cofactor coenzyme A was believed to be produced by biosynthesis from pantothenate in all eukaryotic cells. Rescue experiments in systems depleted of CoA have shown that a phosphorylated CoA biosynthetic intermediate can pass through eukaryotic membranes to serve as an alternative source.
ISSN:1552-4450
1552-4469
DOI:10.1038/nchembio.1912