Drifting toward polymer perfection

The addition of polysialic acid to proteins and cells is emerging as a promising therapeutic strategy. Polysialyltransferases synthesize polymers of widely varying lengths not optimal for therapeutic reagents, but the development of enzyme variants using neutral genetic drift offers a new way to ove...

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Veröffentlicht in:	Nature chemical biology 2014-06, Vol.10 (6), p.410-411
1. Verfasser:	Colley, Karen J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/590 631/92/173 631/92/221 631/92/72 Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemistry Chemistry/Food Science news-and-views
Online-Zugang:	Volltext
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Zusammenfassung:	The addition of polysialic acid to proteins and cells is emerging as a promising therapeutic strategy. Polysialyltransferases synthesize polymers of widely varying lengths not optimal for therapeutic reagents, but the development of enzyme variants using neutral genetic drift offers a new way to overcome this problem.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.1506