The Use of Non-Radioactive Oligonucleotide Probes to Analyze Enzymatically Amplified DNA for Prenatal Diagnosis and Forensic HLA Typing
Non-radioactive oligonucleotide probes for specific alleles of the HLA-DQα and β-globin loci have been synthesized and applied to forensic analysis and prenatal diagnosis. The results obtained with biotin-labeled, enzyme-labeled, and 32 P-labeled probes are compared in the individuality analysis of...
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| Veröffentlicht in: | Bio/Technology 1988-08, Vol.6 (8), p.943-947 |
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| container_title | Bio/Technology |
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| creator | Bugawan, Teodorica L Saiki, Randall K Levenson, Corey H Watson, Robert M Erlich, Henry A |
| description | Non-radioactive oligonucleotide probes for specific alleles of the HLA-DQα and β-globin loci have been synthesized and applied to forensic analysis and prenatal diagnosis. The results obtained with biotin-labeled, enzyme-labeled, and
32
P-labeled probes are compared in the individuality analysis of different autopsy samples and the diagnosis of two fetuses at risk for sickle-cell anemia. |
| doi_str_mv | 10.1038/nbt0888-943 |
| format | Article |
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32
P-labeled probes are compared in the individuality analysis of different autopsy samples and the diagnosis of two fetuses at risk for sickle-cell anemia.</description><identifier>ISSN: 0733-222X</identifier><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 2331-3684</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt0888-943</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Bioinformatics ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Life Sciences ; research-paper</subject><ispartof>Bio/Technology, 1988-08, Vol.6 (8), p.943-947</ispartof><rights>Nature Publishing Company 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c294t-945086ec0ee6a0e3c9888b1310c3d2ea6cf9910fb843cb8e2dc03c95321a38a23</citedby><cites>FETCH-LOGICAL-c294t-945086ec0ee6a0e3c9888b1310c3d2ea6cf9910fb843cb8e2dc03c95321a38a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nbt0888-943$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nbt0888-943$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Bugawan, Teodorica L</creatorcontrib><creatorcontrib>Saiki, Randall K</creatorcontrib><creatorcontrib>Levenson, Corey H</creatorcontrib><creatorcontrib>Watson, Robert M</creatorcontrib><creatorcontrib>Erlich, Henry A</creatorcontrib><title>The Use of Non-Radioactive Oligonucleotide Probes to Analyze Enzymatically Amplified DNA for Prenatal Diagnosis and Forensic HLA Typing</title><title>Bio/Technology</title><addtitle>Nat Biotechnol</addtitle><description>Non-radioactive oligonucleotide probes for specific alleles of the HLA-DQα and β-globin loci have been synthesized and applied to forensic analysis and prenatal diagnosis. The results obtained with biotin-labeled, enzyme-labeled, and
32
P-labeled probes are compared in the individuality analysis of different autopsy samples and the diagnosis of two fetuses at risk for sickle-cell anemia.</description><subject>Agriculture</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Life Sciences</subject><subject>research-paper</subject><issn>0733-222X</issn><issn>1087-0156</issn><issn>2331-3684</issn><issn>1546-1696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNp1kV1LwzAUhoMoOKdX_oF4rdV8dF16WfbhhLGJbOBdSdPTmtElI-mE7g_4t41siDdeHTg854XnPQjdUvJICRdPpmiJECJKY36GeoxzGvFExOeoR4acR4yx90t05f2GkHiYsLiHvlYfgNcesK3wwproTZbaStXqT8DLRtfW7FUDttUl4FdnC_C4tTgzsukOgCfm0G1lq5Vsmg5n212jKw0lHi8yXFkXLsDIVjZ4rGVtrNceS1PiqQ17rxWezTO86nba1NfoopKNh5vT7KP1dLIazaL58vlllM0jxdK4DWIDIhJQBCCRBLhKg25BOSWKlwxkoqo0paQqRMxVIYCVigRowBmVXEjG--j-mKuc9d5Ble-c3krX5ZTkPx3mpw7z0GGgH460D5SpweUbu3dB3v-D3x3xIL138Bv95y38G22OgD0</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>Bugawan, Teodorica L</creator><creator>Saiki, Randall K</creator><creator>Levenson, Corey H</creator><creator>Watson, Robert M</creator><creator>Erlich, Henry A</creator><general>Nature Publishing Group US</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19880801</creationdate><title>The Use of Non-Radioactive Oligonucleotide Probes to Analyze Enzymatically Amplified DNA for Prenatal Diagnosis and Forensic HLA Typing</title><author>Bugawan, Teodorica L ; Saiki, Randall K ; Levenson, Corey H ; Watson, Robert M ; Erlich, Henry A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c294t-945086ec0ee6a0e3c9888b1310c3d2ea6cf9910fb843cb8e2dc03c95321a38a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Agriculture</topic><topic>Bioinformatics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering/Biotechnology</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Life Sciences</topic><topic>research-paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bugawan, Teodorica L</creatorcontrib><creatorcontrib>Saiki, Randall K</creatorcontrib><creatorcontrib>Levenson, Corey H</creatorcontrib><creatorcontrib>Watson, Robert M</creatorcontrib><creatorcontrib>Erlich, Henry A</creatorcontrib><collection>CrossRef</collection><jtitle>Bio/Technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bugawan, Teodorica L</au><au>Saiki, Randall K</au><au>Levenson, Corey H</au><au>Watson, Robert M</au><au>Erlich, Henry A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Use of Non-Radioactive Oligonucleotide Probes to Analyze Enzymatically Amplified DNA for Prenatal Diagnosis and Forensic HLA Typing</atitle><jtitle>Bio/Technology</jtitle><stitle>Nat Biotechnol</stitle><date>1988-08-01</date><risdate>1988</risdate><volume>6</volume><issue>8</issue><spage>943</spage><epage>947</epage><pages>943-947</pages><issn>0733-222X</issn><issn>1087-0156</issn><eissn>2331-3684</eissn><eissn>1546-1696</eissn><abstract>Non-radioactive oligonucleotide probes for specific alleles of the HLA-DQα and β-globin loci have been synthesized and applied to forensic analysis and prenatal diagnosis. The results obtained with biotin-labeled, enzyme-labeled, and
32
P-labeled probes are compared in the individuality analysis of different autopsy samples and the diagnosis of two fetuses at risk for sickle-cell anemia.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><doi>10.1038/nbt0888-943</doi><tpages>5</tpages></addata></record> |
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| issn | 0733-222X 1087-0156 2331-3684 1546-1696 |
| language | eng |
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| source | Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Agriculture Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Life Sciences research-paper |
| title | The Use of Non-Radioactive Oligonucleotide Probes to Analyze Enzymatically Amplified DNA for Prenatal Diagnosis and Forensic HLA Typing |
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