Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144: I. Taxonomy, Fermentation, Isolation and Structural Elucidation

Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144: I. Taxonomy, Fermentation, Isolation and Structural Elucidation

Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus , was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic an...

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Veröffentlicht in:Journal of antibiotics 2008-01, Vol.61 (1), p.1-6
Hauptverfasser: Fukumoto, Atsushi, Kim, Yong-Pil, Matsumoto, Atsuko, Takahashi, Yoko, Shiomi, Kazuro, Tomoda, Hiroshi, Ōmura, Satoshi
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcysteine - administration & dosage
Acetylcysteine - analogs & derivatives
Acetylcysteine - chemistry
Acetylcysteine - isolation & purification
Acetylcysteine - metabolism
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Diterpenes - administration & dosage
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - metabolism
Drug Synergism
Fermentation
Humans
Imipenem - administration & dosage
Life Sciences
Magnetic Resonance Spectroscopy
Medicinal Chemistry
Methicillin Resistance
Microbiology
Microscopy, Electron, Scanning
Molecular Conformation
Molecular Structure
Organic Chemistry
original-article
Staphylococcus aureus - drug effects
Staphylococcus aureus - isolation & purification
Streptomyces - classification
Streptomyces - metabolism
Streptomyces - ultrastructure
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Zusammenfassung:Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus , was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N -acetylcysteine via thioether linkage.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2008.101