The origin of a double insertion of homogeneously staining regions in the house mouse ( )

A high resolution analysis of the G-band patterns of normal and aberrant chromosomes 1, bearing two linked insertions of homogeneously staining regions (HSRs) in the house mouse ( Mus musculus musculus ) reveals the inverted pattern of the euchromatic region between the HSRs. On the basis of this an...

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Veröffentlicht in:	Heredity 1990-10, Vol.65 (2), p.265-267
Hauptverfasser:	Agulnik, S I, Borodin, P M, Gorlov, I P, Ladygina, T Yu, Pak, S D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Chromosome Aberrations - genetics Chromosome Banding Chromosome Inversion Cytogenetics Ecology Evolutionary Biology Fundamental and applied biological sciences. Psychology Gene Amplification - genetics Genetics of eukaryotes. Biological and molecular evolution Human Genetics Mice - genetics Mutagenesis, Insertional - genetics original-article Plant Genetics and Genomics Staining and Labeling Vertebrata
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Beschreibung
Zusammenfassung:	A high resolution analysis of the G-band patterns of normal and aberrant chromosomes 1, bearing two linked insertions of homogeneously staining regions (HSRs) in the house mouse ( Mus musculus musculus ) reveals the inverted pattern of the euchromatic region between the HSRs. On the basis of this analysis a hypothesis on the origin of the aberrant chromosome is put forward: the double insertion is a result of an inversion of the chromosome 1 of Mus musculus domesticus bearing a single insertion of HSR. The proximal breakpoint is localized inside the HSR, and the distal one between subbands E3 and E4.
ISSN:	0018-067X 1365-2540
DOI:	10.1038/hdy.1990.95