Defective DNA repair in Fanconi's anaemia

FIBROBLASTS from patients with Fanconi's anaemia (FA) show increased susceptibility to transformation in vitro by SV40 virus 1 , as well as spontaneous chromosome breakage 2 . Chromosomal instability has also been observed in cultured peripheral blood lymphocytes and in bone marrow cells 3 . Mo...

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Veröffentlicht in:	Nature (London) 1974-07, Vol.250 (5463), p.223-225
Hauptverfasser:	POON, PETER K, O'BRIEN, RICHARD L, PARKER, JOHN W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Aplastic - genetics Chromosome Aberrations DNA - radiation effects DNA Repair Dose-Response Relationship, Radiation Fibroblasts Humanities and Social Sciences Humans letter multidisciplinary Radiation Effects Science Science (multidisciplinary) Thymidine - metabolism Tritium Ultraviolet Rays
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