Defective DNA repair in Fanconi's anaemia

Defective DNA repair in Fanconi's anaemia

FIBROBLASTS from patients with Fanconi's anaemia (FA) show increased susceptibility to transformation in vitro by SV40 virus 1 , as well as spontaneous chromosome breakage 2 . Chromosomal instability has also been observed in cultured peripheral blood lymphocytes and in bone marrow cells 3 . Mo...

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Veröffentlicht in:Nature (London) 1974-07, Vol.250 (5463), p.223-225
Hauptverfasser: POON, PETER K, O'BRIEN, RICHARD L, PARKER, JOHN W
Format: Artikel
Sprache:eng
Schlagworte:
Anemia, Aplastic - genetics
Chromosome Aberrations
DNA - radiation effects
DNA Repair
Dose-Response Relationship, Radiation
Fibroblasts
Humanities and Social Sciences
Humans
letter
multidisciplinary
Radiation Effects
Science
Science (multidisciplinary)
Thymidine - metabolism
Tritium
Ultraviolet Rays
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Zusammenfassung:FIBROBLASTS from patients with Fanconi's anaemia (FA) show increased susceptibility to transformation in vitro by SV40 virus 1 , as well as spontaneous chromosome breakage 2 . Chromosomal instability has also been observed in cultured peripheral blood lymphocytes and in bone marrow cells 3 . More recently, Sasaki and Tonomura 4 demonstrated an increased susceptibility of lymphocytes from patients with FA to chromosome breakage by DNA cross linking agents. These results were interpreted as an indication that FA cells are defective in some DNA repair mechanism.
ISSN:0028-0836
1476-4687
DOI:10.1038/250223a0