The Marmoset as an Animal Model for Teratological Research
AN extensive literature 1 exists in which rodents and rabbits have been used for the production and study of congenital malformations. There is an urgent need for the provision of a suitable near-human model for research in teratology; this became most evident when critical testing in lower mammals...
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| Veröffentlicht in: | Nature (London) 1972-10, Vol.239 (5373), p.460-462 |
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| container_issue | 5373 |
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| container_title | Nature (London) |
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| creator | POSWILLO, D. E HAMILTON, W. J SOPHER, DINAH |
| description | AN extensive literature
1
exists in which rodents and rabbits have been used for the production and study of congenital malformations. There is an urgent need for the provision of a suitable near-human model for research in teratology; this became most evident when critical testing in lower mammals failed to reveal the teratogenic properties exhibited in man by thalidomide. |
| doi_str_mv | 10.1038/239460a0 |
| format | Article |
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1
exists in which rodents and rabbits have been used for the production and study of congenital malformations. There is an urgent need for the provision of a suitable near-human model for research in teratology; this became most evident when critical testing in lower mammals failed to reveal the teratogenic properties exhibited in man by thalidomide.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/239460a0</identifier><identifier>PMID: 4628135</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Abnormalities, Drug-Induced ; Animals ; BIOLOGICAL RADIATION EFFECTS ; Congenital Abnormalities ; Disease Models, Animal ; DRUGS ; EMBRYOS ; EMBRYOS/radioinduced anomalies in marmoset, following in utero exposure, x ; Female ; Fetus - drug effects ; Fetus - radiation effects ; Gestational Age ; Haplorhini - embryology ; HORMONES, SEX/effects on embryos of marmosets exposed in utero, teratogenic ; Humanities and Social Sciences ; IRRADIATION ; letter ; Limb Deformities, Congenital ; LIMBS ; Macaca ; MALFORMATIONS ; Mandible - abnormalities ; MONKEYS ; MONKEYS/radioinduced anomalies in embryos of marmoset, exposed in utero, x ; multidisciplinary ; N48520 --Life Sciences--Radiation Effects on Animals-- Vertebrates ; Papio ; Pregnancy ; Radiation Effects ; RADIATION INJURIES ; Science ; Science (multidisciplinary) ; Thalidomide - adverse effects ; UTERUS ; X RADIATION THALIDOMIDE/effects on embryos of marmosets exposed in utero, teratogenic ; X RADIATION/effects on embryos of marmosets exposed in utero, teratogenic</subject><ispartof>Nature (London), 1972-10, Vol.239 (5373), p.460-462</ispartof><rights>Springer Nature Limited 1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-f5db45136b0c70e7aa75373d97c406c2529d17188098f199e9fe39949f1342543</citedby><cites>FETCH-LOGICAL-c428t-f5db45136b0c70e7aa75373d97c406c2529d17188098f199e9fe39949f1342543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4628135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4599386$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>POSWILLO, D. E</creatorcontrib><creatorcontrib>HAMILTON, W. J</creatorcontrib><creatorcontrib>SOPHER, DINAH</creatorcontrib><creatorcontrib>Royal Coll. of Surgeons of England, London</creatorcontrib><title>The Marmoset as an Animal Model for Teratological Research</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>AN extensive literature
1
exists in which rodents and rabbits have been used for the production and study of congenital malformations. There is an urgent need for the provision of a suitable near-human model for research in teratology; this became most evident when critical testing in lower mammals failed to reveal the teratogenic properties exhibited in man by thalidomide.</description><subject>Abnormalities, Drug-Induced</subject><subject>Animals</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>Congenital Abnormalities</subject><subject>Disease Models, Animal</subject><subject>DRUGS</subject><subject>EMBRYOS</subject><subject>EMBRYOS/radioinduced anomalies in marmoset, following in utero exposure, x</subject><subject>Female</subject><subject>Fetus - drug effects</subject><subject>Fetus - radiation effects</subject><subject>Gestational Age</subject><subject>Haplorhini - embryology</subject><subject>HORMONES, SEX/effects on embryos of marmosets exposed in utero, teratogenic</subject><subject>Humanities and Social Sciences</subject><subject>IRRADIATION</subject><subject>letter</subject><subject>Limb Deformities, Congenital</subject><subject>LIMBS</subject><subject>Macaca</subject><subject>MALFORMATIONS</subject><subject>Mandible - abnormalities</subject><subject>MONKEYS</subject><subject>MONKEYS/radioinduced anomalies in embryos of marmoset, exposed in utero, x</subject><subject>multidisciplinary</subject><subject>N48520 --Life Sciences--Radiation Effects on Animals-- Vertebrates</subject><subject>Papio</subject><subject>Pregnancy</subject><subject>Radiation Effects</subject><subject>RADIATION INJURIES</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Thalidomide - adverse effects</subject><subject>UTERUS</subject><subject>X RADIATION THALIDOMIDE/effects on embryos of marmosets exposed in utero, teratogenic</subject><subject>X RADIATION/effects on embryos of marmosets exposed in utero, teratogenic</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLw0AUhQdRaq2Cf0AJrnQRvZN5d1eKL2gRpK7DdHLTpqSZMpMu_PdGUrtydeGejwPnI-SawiMFpp8yZrgECydkSLmSKZdanZIhQKZT0Eyek4sYNwAgqOIDMuAy05SJIRkv1pjMbdj6iG1iY2KbZNJUW1snc19gnZQ-JAsMtvW1X1Wu-39iRBvc-pKclbaOeHW4I_L18ryYvqWzj9f36WSWOp7pNi1FseSCMrkEpwCVtUowxQqjHAfpMpGZgiqqNRhdUmPQlMiM4aakjGeCsxG563t9bKs8uqpFt3a-adC1ORfGMC076L6HXPAxBizzXehWhO-cQv6rKP9T1KE3PbrbL7dYHMGDky5_6PPYJc0KQ77x-9B0E__ruu3Zxrb7gMeuI_ADhMJ0uQ</recordid><startdate>19721020</startdate><enddate>19721020</enddate><creator>POSWILLO, D. E</creator><creator>HAMILTON, W. J</creator><creator>SOPHER, DINAH</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19721020</creationdate><title>The Marmoset as an Animal Model for Teratological Research</title><author>POSWILLO, D. E ; HAMILTON, W. J ; SOPHER, DINAH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-f5db45136b0c70e7aa75373d97c406c2529d17188098f199e9fe39949f1342543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Abnormalities, Drug-Induced</topic><topic>Animals</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>Congenital Abnormalities</topic><topic>Disease Models, Animal</topic><topic>DRUGS</topic><topic>EMBRYOS</topic><topic>EMBRYOS/radioinduced anomalies in marmoset, following in utero exposure, x</topic><topic>Female</topic><topic>Fetus - drug effects</topic><topic>Fetus - radiation effects</topic><topic>Gestational Age</topic><topic>Haplorhini - embryology</topic><topic>HORMONES, SEX/effects on embryos of marmosets exposed in utero, teratogenic</topic><topic>Humanities and Social Sciences</topic><topic>IRRADIATION</topic><topic>letter</topic><topic>Limb Deformities, Congenital</topic><topic>LIMBS</topic><topic>Macaca</topic><topic>MALFORMATIONS</topic><topic>Mandible - abnormalities</topic><topic>MONKEYS</topic><topic>MONKEYS/radioinduced anomalies in embryos of marmoset, exposed in utero, x</topic><topic>multidisciplinary</topic><topic>N48520 --Life Sciences--Radiation Effects on Animals-- Vertebrates</topic><topic>Papio</topic><topic>Pregnancy</topic><topic>Radiation Effects</topic><topic>RADIATION INJURIES</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Thalidomide - adverse effects</topic><topic>UTERUS</topic><topic>X RADIATION THALIDOMIDE/effects on embryos of marmosets exposed in utero, teratogenic</topic><topic>X RADIATION/effects on embryos of marmosets exposed in utero, teratogenic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>POSWILLO, D. E</creatorcontrib><creatorcontrib>HAMILTON, W. J</creatorcontrib><creatorcontrib>SOPHER, DINAH</creatorcontrib><creatorcontrib>Royal Coll. of Surgeons of England, London</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>POSWILLO, D. E</au><au>HAMILTON, W. J</au><au>SOPHER, DINAH</au><aucorp>Royal Coll. of Surgeons of England, London</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Marmoset as an Animal Model for Teratological Research</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1972-10-20</date><risdate>1972</risdate><volume>239</volume><issue>5373</issue><spage>460</spage><epage>462</epage><pages>460-462</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>AN extensive literature
1
exists in which rodents and rabbits have been used for the production and study of congenital malformations. There is an urgent need for the provision of a suitable near-human model for research in teratology; this became most evident when critical testing in lower mammals failed to reveal the teratogenic properties exhibited in man by thalidomide.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4628135</pmid><doi>10.1038/239460a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1972-10, Vol.239 (5373), p.460-462 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_239460a0 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Abnormalities, Drug-Induced Animals BIOLOGICAL RADIATION EFFECTS Congenital Abnormalities Disease Models, Animal DRUGS EMBRYOS EMBRYOS/radioinduced anomalies in marmoset, following in utero exposure, x Female Fetus - drug effects Fetus - radiation effects Gestational Age Haplorhini - embryology HORMONES, SEX/effects on embryos of marmosets exposed in utero, teratogenic Humanities and Social Sciences IRRADIATION letter Limb Deformities, Congenital LIMBS Macaca MALFORMATIONS Mandible - abnormalities MONKEYS MONKEYS/radioinduced anomalies in embryos of marmoset, exposed in utero, x multidisciplinary N48520 --Life Sciences--Radiation Effects on Animals-- Vertebrates Papio Pregnancy Radiation Effects RADIATION INJURIES Science Science (multidisciplinary) Thalidomide - adverse effects UTERUS X RADIATION THALIDOMIDE/effects on embryos of marmosets exposed in utero, teratogenic X RADIATION/effects on embryos of marmosets exposed in utero, teratogenic |
| title | The Marmoset as an Animal Model for Teratological Research |
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