The Marmoset as an Animal Model for Teratological Research

AN extensive literature 1 exists in which rodents and rabbits have been used for the production and study of congenital malformations. There is an urgent need for the provision of a suitable near-human model for research in teratology; this became most evident when critical testing in lower mammals...

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Veröffentlicht in:	Nature (London) 1972-10, Vol.239 (5373), p.460-462
Hauptverfasser:	POSWILLO, D. E, HAMILTON, W. J, SOPHER, DINAH
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Animals BIOLOGICAL RADIATION EFFECTS Congenital Abnormalities Disease Models, Animal DRUGS EMBRYOS EMBRYOS/radioinduced anomalies in marmoset, following in utero exposure, x Female Fetus - drug effects Fetus - radiation effects Gestational Age Haplorhini - embryology HORMONES, SEX/effects on embryos of marmosets exposed in utero, teratogenic Humanities and Social Sciences IRRADIATION letter Limb Deformities, Congenital LIMBS Macaca MALFORMATIONS Mandible - abnormalities MONKEYS MONKEYS/radioinduced anomalies in embryos of marmoset, exposed in utero, x multidisciplinary N48520 > Life Sciences > Radiation Effects on Animals > Vertebrates Papio Pregnancy Radiation Effects RADIATION INJURIES Science Science (multidisciplinary) Thalidomide - adverse effects UTERUS X RADIATION THALIDOMIDE/effects on embryos of marmosets exposed in utero, teratogenic X RADIATION/effects on embryos of marmosets exposed in utero, teratogenic
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Beschreibung
Zusammenfassung:	AN extensive literature 1 exists in which rodents and rabbits have been used for the production and study of congenital malformations. There is an urgent need for the provision of a suitable near-human model for research in teratology; this became most evident when critical testing in lower mammals failed to reveal the teratogenic properties exhibited in man by thalidomide.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/239460a0