Ion Exchanger from Pearl-shaped Cellulose Gel

WE have described a cellulose gel which allows chromatographic separation of mixtures of high molecular weight substances 1 . It was obtained from cellulose solutions suspended as droplets in an organic solvent. These beads have a rigid structure and they permit diffusion of very large molecules. We also prepared basic and acidic derivatives as possible ion exchangers for proteins. For this purpose cellulose was reacted with 1-chloro-2-diethyl-amino-ethane, α-chloroacetate or propane-sultone.