Inhibition of DNA-dependent RNA Polymerase by 4-Nitroquinoline- N -oxide in Isolated Nuclei

Inhibition of DNA-dependent RNA Polymerase by 4-Nitroquinoline- N -oxide in Isolated Nuclei

4-NITROQUINOLINE- N -OXIDE (4-NQO) is a potent carcinogen 1 and mutagen 2 , which has been shown to induce tumours in mammals 3 , cause nuclear abnormalities in Tetrahymena 4 and induce alterations in tissue culture cell nuclei 5 .

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1967-08, Vol.215 (5102), p.749-750
Hauptverfasser: PAUL, J. S, REYNOLDS, R. C, MONTGOMERY, P. O'B
Format: Artikel
Sprache:eng
Schlagworte:
Carbon Isotopes
Carcinogens - pharmacology
Cell Nucleus
Humanities and Social Sciences
letter
multidisciplinary
Quinolines - pharmacology
RNA Nucleotidyltransferases - analysis
RNA Nucleotidyltransferases - antagonists & inhibitors
Science
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Beschreibung
Zusammenfassung:4-NITROQUINOLINE- N -OXIDE (4-NQO) is a potent carcinogen 1 and mutagen 2 , which has been shown to induce tumours in mammals 3 , cause nuclear abnormalities in Tetrahymena 4 and induce alterations in tissue culture cell nuclei 5 .
ISSN:0028-0836
1476-4687
DOI:10.1038/215749a0