Radioactivity in the Milk of Subjects receiving Radioactive 19-Norsteroids
PREVIOUS studies 1 have provided information about the excretion of radioactive metabolites of orally administered 19-norsteroids in the bile, urine and faeces of human subjects. The experiments described in this report were designed to estimate the amount of a radioactive dose of norethynodrel (17α...
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| Veröffentlicht in: | Nature (London) 1966-11, Vol.212 (5065), p.924-925 |
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| container_issue | 5065 |
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| container_title | Nature (London) |
| container_volume | 212 |
| creator | PINCUS, G. BIALY, G. LAYNE, D. S. PANIAGUA, M. WILLIAMS, K. I. H. |
| description | PREVIOUS studies
1
have provided information about the excretion of radioactive metabolites of orally administered 19-norsteroids in the bile, urine and faeces of human subjects. The experiments described in this report were designed to estimate the amount of a radioactive dose of norethynodrel (17α-ethynyl-17β-hydroxy-Δ
5(10)
-oestren-3-one) or of ethynodiol diacetate (3β,17β-diacetoxy-17α-ethynyl-Δ
4
-oestrene) which was excreted in the milk of rabbits and of humans. |
| doi_str_mv | 10.1038/212924a0 |
| format | Article |
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1
have provided information about the excretion of radioactive metabolites of orally administered 19-norsteroids in the bile, urine and faeces of human subjects. The experiments described in this report were designed to estimate the amount of a radioactive dose of norethynodrel (17α-ethynyl-17β-hydroxy-Δ
5(10)
-oestren-3-one) or of ethynodiol diacetate (3β,17β-diacetoxy-17α-ethynyl-Δ
4
-oestrene) which was excreted in the milk of rabbits and of humans.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/212924a0</identifier><identifier>PMID: 6012386</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological Assay ; ESTROGENS ; Ethynodiol Diacetate - analysis ; Ethynodiol Diacetate - metabolism ; Female ; HORMONES ; Humanities and Social Sciences ; Humans ; LACTATION ; letter ; MICE ; MILK ; Milk - metabolism ; Milk, Human - analysis ; multidisciplinary ; N28130 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Metabolism, Physiology & Toxicology ; Norethynodrel - analysis ; Norethynodrel - metabolism ; Norsteroids - analysis ; Norsteroids - metabolism ; Organ Size ; Pregnancy ; RABBITS ; Radiation Monitoring ; RADIOACTIVITY ; Radiobiology ; Science ; Science (multidisciplinary) ; SEX ; SPECTROMETERS ; STEROIDS ; TISSUES ; Tritium - metabolism ; UTERUS</subject><ispartof>Nature (London), 1966-11, Vol.212 (5065), p.924-925</ispartof><rights>Springer Nature Limited 1966</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2540-f6e4b9560cde68def5c1d5599e102cac4058a9e742aca1b8124d1b115fd888003</citedby><cites>FETCH-LOGICAL-c2540-f6e4b9560cde68def5c1d5599e102cac4058a9e742aca1b8124d1b115fd888003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/212924a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/212924a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6012386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4463383$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>PINCUS, G.</creatorcontrib><creatorcontrib>BIALY, G.</creatorcontrib><creatorcontrib>LAYNE, D. S.</creatorcontrib><creatorcontrib>PANIAGUA, M.</creatorcontrib><creatorcontrib>WILLIAMS, K. I. H.</creatorcontrib><creatorcontrib>Worcester Foundation for Experimental Biology, Shrewsbury, Mass</creatorcontrib><title>Radioactivity in the Milk of Subjects receiving Radioactive 19-Norsteroids</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>PREVIOUS studies
1
have provided information about the excretion of radioactive metabolites of orally administered 19-norsteroids in the bile, urine and faeces of human subjects. The experiments described in this report were designed to estimate the amount of a radioactive dose of norethynodrel (17α-ethynyl-17β-hydroxy-Δ
5(10)
-oestren-3-one) or of ethynodiol diacetate (3β,17β-diacetoxy-17α-ethynyl-Δ
4
-oestrene) which was excreted in the milk of rabbits and of humans.</description><subject>Animals</subject><subject>Biological Assay</subject><subject>ESTROGENS</subject><subject>Ethynodiol Diacetate - analysis</subject><subject>Ethynodiol Diacetate - metabolism</subject><subject>Female</subject><subject>HORMONES</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>LACTATION</subject><subject>letter</subject><subject>MICE</subject><subject>MILK</subject><subject>Milk - metabolism</subject><subject>Milk, Human - analysis</subject><subject>multidisciplinary</subject><subject>N28130 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Metabolism, Physiology & Toxicology</subject><subject>Norethynodrel - analysis</subject><subject>Norethynodrel - metabolism</subject><subject>Norsteroids - analysis</subject><subject>Norsteroids - metabolism</subject><subject>Organ Size</subject><subject>Pregnancy</subject><subject>RABBITS</subject><subject>Radiation Monitoring</subject><subject>RADIOACTIVITY</subject><subject>Radiobiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>SEX</subject><subject>SPECTROMETERS</subject><subject>STEROIDS</subject><subject>TISSUES</subject><subject>Tritium - metabolism</subject><subject>UTERUS</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0E1LAzEQBuAgSq1V8A8IwZMeVifZbDZ7lOInVcGP85JNZtvUdlOSrdB_78pWPXiaw_swzLyEHDO4YJCqS854wYWGHTJkIpeJkCrfJUMArhJQqdwnBzHOASBjuRiQgQTGUyWH5OFFW-e1ad2nazfUNbSdIX10iw_qa_q6ruZo2kgDGuxEM6V_HikrkicfYovBOxsPyV6tFxGPtnNE3m-u38Z3yeT59n58NUkMzwQktURRFZkEY1Eqi3VmmM2yokAG3GgjIFO6wFxwbTSrFOPCsoqxrLZKKYB0RE77vT62rozGtWhmxjdNd2kphExTlXborEcm-BgD1uUquKUOm5JB-V1Z-VNZR096ulpXS7S_cNtRl5_3eeySZoqhnPt1aLoX_-_6AsE9chQ</recordid><startdate>19661126</startdate><enddate>19661126</enddate><creator>PINCUS, G.</creator><creator>BIALY, G.</creator><creator>LAYNE, D. 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H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2540-f6e4b9560cde68def5c1d5599e102cac4058a9e742aca1b8124d1b115fd888003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Animals</topic><topic>Biological Assay</topic><topic>ESTROGENS</topic><topic>Ethynodiol Diacetate - analysis</topic><topic>Ethynodiol Diacetate - metabolism</topic><topic>Female</topic><topic>HORMONES</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>LACTATION</topic><topic>letter</topic><topic>MICE</topic><topic>MILK</topic><topic>Milk - metabolism</topic><topic>Milk, Human - analysis</topic><topic>multidisciplinary</topic><topic>N28130 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Metabolism, Physiology & Toxicology</topic><topic>Norethynodrel - analysis</topic><topic>Norethynodrel - metabolism</topic><topic>Norsteroids - analysis</topic><topic>Norsteroids - metabolism</topic><topic>Organ Size</topic><topic>Pregnancy</topic><topic>RABBITS</topic><topic>Radiation Monitoring</topic><topic>RADIOACTIVITY</topic><topic>Radiobiology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>SEX</topic><topic>SPECTROMETERS</topic><topic>STEROIDS</topic><topic>TISSUES</topic><topic>Tritium - metabolism</topic><topic>UTERUS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PINCUS, G.</creatorcontrib><creatorcontrib>BIALY, G.</creatorcontrib><creatorcontrib>LAYNE, D. S.</creatorcontrib><creatorcontrib>PANIAGUA, M.</creatorcontrib><creatorcontrib>WILLIAMS, K. I. H.</creatorcontrib><creatorcontrib>Worcester Foundation for Experimental Biology, Shrewsbury, Mass</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PINCUS, G.</au><au>BIALY, G.</au><au>LAYNE, D. S.</au><au>PANIAGUA, M.</au><au>WILLIAMS, K. I. H.</au><aucorp>Worcester Foundation for Experimental Biology, Shrewsbury, Mass</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioactivity in the Milk of Subjects receiving Radioactive 19-Norsteroids</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1966-11-26</date><risdate>1966</risdate><volume>212</volume><issue>5065</issue><spage>924</spage><epage>925</epage><pages>924-925</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>PREVIOUS studies
1
have provided information about the excretion of radioactive metabolites of orally administered 19-norsteroids in the bile, urine and faeces of human subjects. The experiments described in this report were designed to estimate the amount of a radioactive dose of norethynodrel (17α-ethynyl-17β-hydroxy-Δ
5(10)
-oestren-3-one) or of ethynodiol diacetate (3β,17β-diacetoxy-17α-ethynyl-Δ
4
-oestrene) which was excreted in the milk of rabbits and of humans.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6012386</pmid><doi>10.1038/212924a0</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Animals Biological Assay ESTROGENS Ethynodiol Diacetate - analysis Ethynodiol Diacetate - metabolism Female HORMONES Humanities and Social Sciences Humans LACTATION letter MICE MILK Milk - metabolism Milk, Human - analysis multidisciplinary N28130 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Metabolism, Physiology & Toxicology Norethynodrel - analysis Norethynodrel - metabolism Norsteroids - analysis Norsteroids - metabolism Organ Size Pregnancy RABBITS Radiation Monitoring RADIOACTIVITY Radiobiology Science Science (multidisciplinary) SEX SPECTROMETERS STEROIDS TISSUES Tritium - metabolism UTERUS |
| title | Radioactivity in the Milk of Subjects receiving Radioactive 19-Norsteroids |
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