Radioactivity in the Milk of Subjects receiving Radioactive 19-Norsteroids

PREVIOUS studies 1 have provided information about the excretion of radioactive metabolites of orally administered 19-norsteroids in the bile, urine and faeces of human subjects. The experiments described in this report were designed to estimate the amount of a radioactive dose of norethynodrel (17α...

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Veröffentlicht in:	Nature (London) 1966-11, Vol.212 (5065), p.924-925
Hauptverfasser:	PINCUS, G., BIALY, G., LAYNE, D. S., PANIAGUA, M., WILLIAMS, K. I. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay ESTROGENS Ethynodiol Diacetate - analysis Ethynodiol Diacetate - metabolism Female HORMONES Humanities and Social Sciences Humans LACTATION letter MICE MILK Milk - metabolism Milk, Human - analysis multidisciplinary N28130 -Life Sciences-Biochemistry, Physiology, & Molecular Biology-Metabolism, Physiology & Toxicology Norethynodrel - analysis Norethynodrel - metabolism Norsteroids - analysis Norsteroids - metabolism Organ Size Pregnancy RABBITS Radiation Monitoring RADIOACTIVITY Radiobiology Science Science (multidisciplinary) SEX SPECTROMETERS STEROIDS TISSUES Tritium - metabolism UTERUS
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Zusammenfassung:	PREVIOUS studies 1 have provided information about the excretion of radioactive metabolites of orally administered 19-norsteroids in the bile, urine and faeces of human subjects. The experiments described in this report were designed to estimate the amount of a radioactive dose of norethynodrel (17α-ethynyl-17β-hydroxy-Δ 5(10) -oestren-3-one) or of ethynodiol diacetate (3β,17β-diacetoxy-17α-ethynyl-Δ 4 -oestrene) which was excreted in the milk of rabbits and of humans.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/212924a0