γ-Guanidinobutyric Acid as a Convulsive Substance

γ-Guanidinobutyric Acid as a Convulsive Substance

IRREVERKE et al. 1,2 have demonstrated the presence of γ-guanidinobutyric acid in the brain, kidney and liver of animals, using paper chromatography, and have isolated the substance in pure form from calf brain. Pisano, Mitoma and Udenfriend 3 demonstrated that γ-guanidino-butyric acid is produced f...

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Veröffentlicht in:Nature (London) 1966-11, Vol.212 (5062), p.617-617
Hauptverfasser: JINNAI, DENNOSUKE, SAWAI, AIJIRO, MORI, AKITANE
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Butyrates - pharmacology
Electroencephalography
Guanidines - pharmacology
Humanities and Social Sciences
letter
multidisciplinary
Rabbits
Science
Seizures - chemically induced
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Zusammenfassung:IRREVERKE et al. 1,2 have demonstrated the presence of γ-guanidinobutyric acid in the brain, kidney and liver of animals, using paper chromatography, and have isolated the substance in pure form from calf brain. Pisano, Mitoma and Udenfriend 3 demonstrated that γ-guanidino-butyric acid is produced from y-aminobutyric acid and arginine by transamidinase activity in mammalian kidney. The present communication describes the seizures caused by administration of the compound to rabbits.
ISSN:0028-0836
1476-4687
DOI:10.1038/212617a0