Antiviral Activity of Gliotoxin and Gliotoxin Acetate

DURING a search for antiviral materials, we found several Penicillium culture filtrates that inhibited the cytopathic effect of type 2 poliovirus MEF 1 in monkey kidney primary cell cultures. The antipolio activity of these filtrates was found to be due to gliotoxin and gliotoxin acetate.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1964-12, Vol.204 (4965), p.1333-1334
Hauptverfasser:	RIGHTSEL, WILTON A, SCHNEIDER, HORST G, SLOAN, BERNARD J, GRAF, PERSIS R, MILLER, FRANCIS A, BARTZ, QUENTIN R, EHRLICH, JOHN, DIXON, GLEN J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Animals Antitoxins Antiviral Agents Enterovirus Enterovirus B, Human Gliotoxin Humanities and Social Sciences letter Measles virus Mice multidisciplinary Orthomyxoviridae Paramyxoviridae Infections Penicillium Poliovirus Science Science (multidisciplinary) Simplexvirus Toxicology Toxins, Biological Vaccinia virus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	DURING a search for antiviral materials, we found several Penicillium culture filtrates that inhibited the cytopathic effect of type 2 poliovirus MEF 1 in monkey kidney primary cell cultures. The antipolio activity of these filtrates was found to be due to gliotoxin and gliotoxin acetate.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/2041333b0