Effect of a New Anticancer Agent, 1,4-Dimethyl-1,4-Diphenyl-2-Tetrazene, on a Transplantable Mammary Adenocarcinoma (72j) and Spontaneous Mouse Breast Tumours

1,4-DIMETHYL-1,4-DIPHENYIL-2-TETRAZENE 1 (MPT) inhibits the growth of transplanted 72 j mammary adenocarcinoma carried in C 3 H mice. Its activity was found during the screening 2,3 of compounds structurally related to the antineoplastic agent 3,3-dimethyl-1-phenyltriazene 4 . The corresponding 1,4-diethyl 5 and 1,4-di( p -nitrophenyl) analogues of MPT were also found active against this tumour. Extensive laboratory evaluation of MPT and synthesis of additional compounds are in progress and will be reported in detail 6,7 . The following biological findings were considered to be of immediate interest.