Synthesis of the Toxic Principle of Dichapetalum toxicarium (18-Fluoro- cis -9-Octadecenoic Acid)
Dichapetalum toxicarium ( Chailletia toxicaria , Don). a shrub occurring in Sierra Leone, produces a hard and woody fruit which is extremely toxic to warm-blooded animals. The pharmacological, medical, and historical aspects of this plant have recently been reviewed 1 . Peters and colleagues have co...
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| Veröffentlicht in: | Nature (London) 1961-12, Vol.192 (4809), p.1284-1285 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Dichapetalum toxicarium
(
Chailletia toxicaria
, Don). a shrub occurring in Sierra Leone, produces a hard and woody fruit which is extremely toxic to warm-blooded animals. The pharmacological, medical, and historical aspects of this plant have recently been reviewed
1
. Peters and colleagues have concluded
2
, on the basis of nuclear magnetic resonance, infra-red spectroscopy and ozonolysis, that the toxic principle is 18-fluoro-
cis
-9-octadecenoic acid (ω-fluoro-oleic acid), F(CH
2
)
8
CH=CH(CH
2
)
7
COOH. It was in order to confirm this conclusion that the following synthesis of ω-fluoro-oleic acid was undertaken: |
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| ISSN: | 0028-0836 1476-4687 |
| DOI: | 10.1038/1921284a0 |