A Dominant Gene for Renal Adenomas in the Rat

FAMILIAL renal adenomas in the rat have been described in a previous report 1 . They usually occurred as multiple tumours and were bilateral. The tumours were simple cysts, papillary cystadenomas, solid eosinophile adenomas or solid basophile tubular adenomas. They varied in size from barely visible to large growths which included almost the entire kidney (Fig. 1). The material consisted of a number of individuals from a line of Wistar rats maintained in this laboratory, indicating that the condition was genetically controlled.